Celebrated psychoanalyst and author Dr. Margaret Ford has a new client, Billy, who is addicted to sex, drugs, and gambling at an illicit poker lounge known as the House of Games. Seeking material for her next bestseller, Dr. Ford ventures into Chicago's underworld, where she encounters Mike, a charismatic gambler. A complex game ensues, blurring the lines between player and pawn, as they navigate a world where the rules are constantly changing.