Set against the backdrop of 1950s Puerto Rico, "Las Borinqueñas" weaves a captivating tale of Maria, Fernanda, Yolanda, Rosa, and Chavela. In a society entrenched with oppressive rules for women, these resilient individuals strive for a life beyond societal expectations. Their compelling stories unfold within the transformative era when societal norms are challenged and a groundbreaking development is underway in the United States.

In the U.S., Dr. Gregory Pincus is on the verge of a groundbreaking discovery – the birth control pill. However, his quest faces a crucial obstacle: finding courageous women willing to participate in the preliminary trials. As the lives of these Puerto Rican women and Dr. Pincus intersect, "Las Borinqueñas" becomes a poignant narrative of bravery, defiance, and the pursuit of freedom. This gripping drama explores the intertwined destinies of those who dared to defy societal norms, offering a profound reflection on the indomitable spirit that emerges in the face of adversity.